Assay Detail
Functional
CHEMBL4333175
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Agonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins
10
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.83 | 7.40 |
| Emax | 3 | - | - |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429731 | — | — | 2 | 7.40 |
| CHEMBL4449491 | — | — | 4 | 6.80 |
| CHEMBL4442534 | — | — | 4 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429731 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4449491 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4449491 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4442534 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4442534 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4442534 | — | Emax | = | 31.28 | % | - |
| CHEMBL4442534 | — | Inhibition | - | % | - | |
| CHEMBL4449491 | — | Emax | = | 26.56 | % | - |
| CHEMBL4449491 | — | Inhibition | - | % | - | |
| CHEMBL429731 | — | Emax | = | 52.2 | % | - |