Assay Detail
Binding
CHEMBL4333216
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Activation of Keap1/Cul3/Nrf2 in human BEAS2B cells assessed as increase in NQO1 levels measured after 48 hrs
8
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.10 | 8.06 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | 3.0 | 1 | 8.06 |
| CHEMBL4573284 | — | — | 1 | 5.80 |
| CHEMBL4245297 | — | — | 1 | 5.80 |
| CHEMBL4554334 | — | — | 1 | 5.80 |
| CHEMBL4514848 | — | — | 1 | 5.80 |
| CHEMBL4474353 | — | — | 2 | 5.78 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | EC50 | = | 8.71 | nM | 8.06 |
| CHEMBL4573284 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4245297 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4554334 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4514848 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4474353 | — | EC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL48802 | SULFORAPHANE | EC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL4474353 | — | Activity | - | — | - |