Assay Detail
Functional
CHEMBL4333754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote stage of Leishmania infantum MHOM/MA(BE)/67 infected in mouse primary peritoneal macrophages assessed as decrease in parasite burden after 5 days by Giemsa staining-based microscopic method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimicrobial activities of N<sup>6</sup>-hydroxyagelasine analogs and revision of the structure of ageloximes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.23 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592498 | — | — | 1 | 5.67 |
| CHEMBL4469221 | — | — | 1 | 5.62 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.93 |
| CHEMBL4443174 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592498 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4469221 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4443174 | — | IC50 | = | 20300.0 | nM | 4.69 |