Assay Detail
Functional
CHEMBL4333780
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Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | PAM212 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.32 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 7.00 |
| CHEMBL4530544 | — | — | 1 | 5.40 |
| CHEMBL4447259 | — | — | 1 | 4.48 |
| CHEMBL4590323 | — | — | 1 | 4.40 |
| CHEMBL4461152 | — | — | 1 | - |
| CHEMBL4464972 | — | — | 1 | - |
| CHEMBL4471393 | — | — | 1 | - |
| CHEMBL4465447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416 | METHOXSALEN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4530544 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4447259 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4590323 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4461152 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4464972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4471393 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL4465447 | — | IC50 | > | 100000.0 | nM | - |