Assay Detail
Functional
CHEMBL4333829
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Inhibition of LPS-stimulated TNFalpha production in human neutrophils after 24 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Eupatoriopicrin Inhibits Pro-inflammatory Functions of Neutrophils via Suppression of IL-8 and TNF-alpha Production and p38 and ERK 1/2 MAP Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436522 | — | — | 1 | 7.05 |
| CHEMBL4590522 | — | — | 1 | 7.00 |
| CHEMBL4463052 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436522 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4590522 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4463052 | — | IC50 | = | 120.0 | nM | 6.92 |