Assay Detail
Functional
CHEMBL4333841
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Antiproliferative activity against human MCF7 cells after 5 days by CellTiter-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.49 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4563316 | — | — | 1 | 10.00 |
| CHEMBL4447340 | — | — | 1 | 10.00 |
| CHEMBL4438992 | — | — | 1 | 9.70 |
| CHEMBL4524752 | — | — | 1 | 9.70 |
| CHEMBL4435067 | — | — | 1 | 9.70 |
| CHEMBL4438260 | — | — | 1 | 9.70 |
| CHEMBL4464718 | — | — | 1 | 9.52 |
| CHEMBL4576272 | — | — | 1 | 9.52 |
| CHEMBL4454014 | — | — | 1 | 9.40 |
| CHEMBL4438826 | — | — | 1 | 9.40 |
| CHEMBL4574167 | — | — | 1 | 9.40 |
| CHEMBL4461269 | — | — | 1 | 8.85 |
| CHEMBL4450664 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4563316 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4447340 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4438992 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4524752 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4435067 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4438260 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4464718 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4576272 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4454014 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4438826 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4574167 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4461269 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4450664 | — | IC50 | = | 3.6 | nM | 8.44 |