Assay Detail
Binding
CHEMBL4334555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.14 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522149 | — | — | 1 | 7.89 |
| CHEMBL4476049 | — | — | 1 | 7.83 |
| CHEMBL4539004 | — | — | 1 | 7.79 |
| CHEMBL4583725 | — | — | 1 | 7.67 |
| CHEMBL4455083 | — | — | 1 | 7.56 |
| CHEMBL4580143 | — | — | 1 | 7.56 |
| CHEMBL4549502 | — | — | 1 | 7.38 |
| CHEMBL4458544 | — | — | 1 | 7.37 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.00 |
| CHEMBL4461005 | — | — | 1 | 6.89 |
| CHEMBL4577419 | — | — | 1 | 6.87 |
| CHEMBL4562808 | — | — | 1 | 6.83 |
| CHEMBL4066043 | — | — | 1 | 5.68 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522149 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4476049 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4539004 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL4583725 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL4455083 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL4580143 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL4549502 | — | IC50 | = | 41.9 | nM | 7.38 |
| CHEMBL4458544 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4461005 | — | IC50 | = | 128.4 | nM | 6.89 |
| CHEMBL4577419 | — | IC50 | = | 134.1 | nM | 6.87 |
| CHEMBL4562808 | — | IC50 | = | 147.5 | nM | 6.83 |
| CHEMBL4066043 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 2490.0 | nM | 5.60 |