Assay Detail
Binding
CHEMBL4334556
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Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583725 | — | — | 1 | 8.00 |
| CHEMBL4455083 | — | — | 1 | 7.97 |
| CHEMBL4577419 | — | — | 1 | 7.90 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.85 |
| CHEMBL4580143 | — | — | 1 | 7.84 |
| CHEMBL4476049 | — | — | 1 | 7.83 |
| CHEMBL4539004 | — | — | 1 | 7.78 |
| CHEMBL4522149 | — | — | 1 | 7.71 |
| CHEMBL4461005 | — | — | 1 | 7.69 |
| CHEMBL4549502 | — | — | 1 | 7.60 |
| CHEMBL4562808 | — | — | 1 | 7.58 |
| CHEMBL4458544 | — | — | 1 | 7.51 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.46 |
| CHEMBL4066043 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583725 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4455083 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL4577419 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4580143 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4476049 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4539004 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4522149 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL4461005 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL4549502 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4562808 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4458544 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL4066043 | — | IC50 | = | 85.0 | nM | 7.07 |