Assay Detail
Functional
CHEMBL4334559
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Antiproliferative activity against human IMR32 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.14 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458544 | — | — | 1 | 6.68 |
| CHEMBL4580143 | — | — | 1 | 6.58 |
| CHEMBL4522149 | — | — | 1 | 6.52 |
| CHEMBL4583725 | — | — | 1 | 6.51 |
| CHEMBL4455083 | — | — | 1 | 6.26 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.21 |
| CHEMBL4539004 | — | — | 1 | 6.20 |
| CHEMBL4476049 | — | — | 1 | 6.08 |
| CHEMBL4549502 | — | — | 1 | 5.96 |
| CHEMBL4461005 | — | — | 1 | 5.86 |
| CHEMBL4577419 | — | — | 1 | 5.63 |
| CHEMBL4562808 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458544 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4580143 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4522149 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4583725 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4455083 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4539004 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4476049 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4549502 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4461005 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4577419 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4562808 | — | IC50 | = | 6040.0 | nM | 5.22 |