Assay Detail
Functional
CHEMBL4334671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.22 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4543719 | — | — | 1 | 5.64 |
| CHEMBL4518361 | — | — | 1 | 5.60 |
| CHEMBL523296 | UVARETIN | — | 1 | 5.44 |
| CHEMBL4563176 | — | — | 1 | 5.38 |
| CHEMBL4537024 | — | — | 1 | 5.23 |
| CHEMBL440948 | — | — | 1 | 5.17 |
| CHEMBL4580701 | — | — | 1 | 5.17 |
| CHEMBL4462275 | — | — | 1 | 5.14 |
| CHEMBL4435440 | — | — | 1 | 5.13 |
| CHEMBL4438131 | — | — | 1 | 5.12 |
| CHEMBL4569822 | — | — | 1 | 5.09 |
| CHEMBL4592074 | — | — | 1 | 4.93 |
| CHEMBL4463712 | — | — | 1 | 4.88 |
| CHEMBL4524157 | — | — | 1 | - |
| CHEMBL104255 | FLAVOKAWAIN B | — | 1 | - |
| CHEMBL450288 | XANTHOXYLIN | — | 1 | - |
| CHEMBL1734430 | — | — | 1 | - |
| CHEMBL452477 | 2,4,6-TRIHYDROXYACETOPHENONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4543719 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4518361 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL523296 | UVARETIN | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4563176 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4537024 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL440948 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4580701 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4462275 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4435440 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4438131 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4569822 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4592074 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4463712 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4524157 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | > | 20000.0 | nM | - |
| CHEMBL450288 | XANTHOXYLIN | IC50 | > | 20000.0 | nM | - |
| CHEMBL1734430 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL452477 | 2,4,6-TRIHYDROXYACETOPHENONE | IC50 | > | 20000.0 | nM | - |