Assay Detail
Functional
CHEMBL4334812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against drug-resistant human MDA-MB-435/LCC6MDR1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.63 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445947 | — | — | 1 | 5.41 |
| CHEMBL4554686 | — | — | 1 | 5.11 |
| CHEMBL4559128 | — | — | 1 | 5.10 |
| CHEMBL4454231 | — | — | 1 | 5.02 |
| CHEMBL1935213 | — | — | 1 | 4.91 |
| CHEMBL4469707 | — | — | 1 | 4.80 |
| CHEMBL17200 | — | — | 1 | 4.71 |
| CHEMBL4566283 | — | — | 1 | 4.68 |
| CHEMBL4476356 | — | — | 1 | 4.60 |
| CHEMBL4581268 | — | — | 1 | 4.53 |
| CHEMBL4468505 | — | — | 1 | 4.51 |
| CHEMBL4514655 | — | — | 1 | 4.36 |
| CHEMBL1935214 | — | — | 1 | 4.34 |
| CHEMBL4549846 | — | — | 1 | 4.31 |
| CHEMBL4518018 | — | — | 1 | 4.17 |
| CHEMBL4473797 | — | — | 1 | 4.09 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 4.08 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
| CHEMBL4563547 | — | — | 1 | - |
| CHEMBL4449722 | — | — | 1 | - |
| CHEMBL4566759 | — | — | 1 | - |
| CHEMBL1935209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445947 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4554686 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4559128 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4454231 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL1935213 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4469707 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL17200 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4566283 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4476356 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4581268 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL4468505 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL4514655 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL1935214 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL4549846 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL4518018 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL4473797 | — | IC50 | = | 80900.0 | nM | 4.09 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 82300.0 | nM | 4.08 |
| CHEMBL185 | FLUOROURACIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL4563547 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4449722 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4566759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1935209 | — | IC50 | > | 100000.0 | nM | - |