Assay Detail
Functional
CHEMBL4334813
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Cytotoxicity against drug-resistant TCCD-induced human MCF7 cells overexpressing CYP1B1 assessed as reduction in cell viability after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.57 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554686 | — | — | 1 | 4.95 |
| CHEMBL4559128 | — | — | 1 | 4.90 |
| CHEMBL4469707 | — | — | 1 | 4.83 |
| CHEMBL4454231 | — | — | 1 | 4.82 |
| CHEMBL17200 | — | — | 1 | 4.74 |
| CHEMBL4563547 | — | — | 1 | 4.69 |
| CHEMBL4473797 | — | — | 1 | 4.62 |
| CHEMBL4476356 | — | — | 1 | 4.58 |
| CHEMBL1935209 | — | — | 1 | 4.49 |
| CHEMBL4518018 | — | — | 1 | 4.47 |
| CHEMBL4566283 | — | — | 1 | 4.38 |
| CHEMBL1935213 | — | — | 1 | 4.37 |
| CHEMBL4445947 | — | — | 1 | 4.36 |
| CHEMBL4468505 | — | — | 1 | 4.34 |
| CHEMBL1935214 | — | — | 1 | 4.32 |
| CHEMBL4581268 | — | — | 1 | 4.19 |
| CHEMBL4514655 | — | — | 1 | - |
| CHEMBL4566759 | — | — | 1 | - |
| CHEMBL4549846 | — | — | 1 | - |
| CHEMBL4449722 | — | — | 1 | - |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554686 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4559128 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4469707 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4454231 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL17200 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4563547 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4473797 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL4476356 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL1935209 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4518018 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4566283 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL1935213 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL4445947 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL4468505 | — | IC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL1935214 | — | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL4581268 | — | IC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL4514655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4566759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4549846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4449722 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | > | 100000.0 | nM | - |