Assay Detail
Functional
CHEMBL4335367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days by qRT-PCR analysis
37
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 6.07 | 8.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454780 | — | — | 2 | 8.30 |
| CHEMBL4558413 | — | — | 1 | 8.10 |
| CHEMBL4440322 | — | — | 1 | 7.46 |
| CHEMBL4587683 | — | — | 1 | 7.18 |
| CHEMBL4437532 | — | — | 1 | 7.00 |
| CHEMBL4569351 | — | — | 1 | 6.96 |
| CHEMBL4553813 | — | — | 1 | 6.77 |
| CHEMBL4515442 | — | — | 1 | 6.62 |
| CHEMBL4453784 | — | — | 1 | 6.54 |
| CHEMBL4081254 | — | — | 1 | 6.44 |
| CHEMBL4450279 | — | — | 1 | 6.44 |
| CHEMBL4060939 | — | — | 1 | 6.44 |
| CHEMBL4464425 | — | — | 1 | 6.14 |
| CHEMBL4592542 | — | — | 1 | 6.12 |
| CHEMBL4470434 | — | — | 1 | 6.08 |
| CHEMBL4440902 | — | — | 1 | 6.01 |
| CHEMBL4438572 | — | — | 1 | 6.00 |
| CHEMBL4517692 | — | — | 1 | 5.98 |
| CHEMBL4457294 | — | — | 1 | 5.85 |
| CHEMBL4553087 | — | — | 1 | 5.80 |
| CHEMBL4544401 | — | — | 1 | 5.75 |
| CHEMBL4547041 | — | — | 1 | 5.73 |
| CHEMBL4457351 | — | — | 1 | 5.72 |
| CHEMBL4458471 | — | — | 1 | 5.66 |
| CHEMBL4464300 | — | — | 1 | 5.63 |
| CHEMBL4547820 | — | — | 1 | 5.61 |
| CHEMBL4581931 | — | — | 1 | 5.59 |
| CHEMBL4574761 | — | — | 1 | 5.46 |
| CHEMBL4454581 | — | — | 1 | 5.44 |
| CHEMBL4549343 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454780 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4558413 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4440322 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4587683 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4437532 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4569351 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4553813 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4515442 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4453784 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4450279 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4060939 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4081254 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4464425 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4592542 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4470434 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4440902 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4438572 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4517692 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4457294 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4553087 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4544401 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4547041 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4457351 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4458471 | — | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4464300 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4547820 | — | EC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4581931 | — | EC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4574761 | — | EC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4454581 | — | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4549343 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4439505 | — | EC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4590990 | — | EC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL4591439 | — | EC50 | = | 16650.0 | nM | 4.78 |
| CHEMBL4473743 | — | EC50 | = | 25560.0 | nM | 4.59 |
| CHEMBL4442364 | — | EC50 | = | 28120.0 | nM | 4.55 |
| CHEMBL4461601 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4454780 | — | Activity | - | — | - |