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Assay Detail

CHEMBL4335388

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against DENV infected in human Huh7.5.1 cells assessed as inhibition of viral replication measured after 3 days by qRT-PCR analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Dengue virus
Confidence 1 — Organism
Curated By Autocuration

Target

Dengue virus (CHEMBL613757)
Type ORGANISM
Organism Dengue virus

Publication

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.
Yang Y, Cao L, Gao H, Wu Y, Wang Y, Fang F, Lan T, Lou Z, Rao Y.
J Med Chem (2019) 62 : 4056 -4073
PubMed 30938999 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.15 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4454780 1 8.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4454780 EC50 = 7.0 nM 8.15