Assay Detail
Binding
CHEMBL4335416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6-His tagged recombinant human DHODH N-terminal domain delta29 mutant expressed in Escherichia coli BL21(DE3) using dihydroorotate as substrate measured every 30 secs for 6 mins by DCIP dye based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.59 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454780 | — | — | 1 | 7.22 |
| CHEMBL4558413 | — | — | 1 | 6.60 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 6.55 |
| CHEMBL4461601 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454780 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4558413 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4461601 | — | IC50 | = | 1030.0 | nM | 5.99 |