Assay Detail
Binding
CHEMBL4335546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MKK7 beta1 S273D/T275D double mutant (unknown origin) using JNK1 K55M mutant as substrate by ADP-Glo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.73 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072299 | — | — | 1 | 8.07 |
| CHEMBL4103201 | — | — | 1 | 7.72 |
| CHEMBL4091966 | — | — | 1 | 7.46 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 7.11 |
| CHEMBL4090601 | — | — | 1 | 6.95 |
| CHEMBL4095447 | — | — | 1 | 6.83 |
| CHEMBL4062509 | — | — | 1 | 6.81 |
| CHEMBL2180204 | — | — | 1 | 6.80 |
| CHEMBL4094959 | — | — | 1 | 6.52 |
| CHEMBL4099254 | — | — | 1 | 6.51 |
| CHEMBL4099713 | — | — | 1 | 6.38 |
| CHEMBL4094527 | — | — | 1 | 6.20 |
| CHEMBL2180203 | — | — | 1 | 6.18 |
| CHEMBL4082783 | — | — | 1 | 5.80 |
| CHEMBL4101735 | — | — | 1 | 5.58 |
| CHEMBL4081698 | — | — | 1 | - |
| CHEMBL4103121 | — | — | 1 | - |
| CHEMBL4083739 | — | — | 1 | - |
| CHEMBL4463840 | — | — | 1 | - |
| CHEMBL4452101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072299 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4103201 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4091966 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4090601 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4095447 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4062509 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL2180204 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4094959 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4099254 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4099713 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4094527 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL2180203 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL4082783 | — | IC50 | = | 1572.0 | nM | 5.80 |
| CHEMBL4101735 | — | IC50 | = | 2611.0 | nM | 5.58 |
| CHEMBL4081698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4103121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4083739 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4463840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452101 | — | IC50 | > | 10000.0 | nM | - |