Assay Detail
Binding
CHEMBL4335799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit skeletal muscle alpha-actin polymerization measured after 24 hrs in presence of ATP and fluorescent pyrene-labelled actin by fluorescence based assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Actin, alpha skeletal muscle (CHEMBL4523260) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Chivosazole A Modulates Protein-Protein Interactions of Actin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.95 | 5.07 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411879 | LATRUNCULIN B | — | 2 | 5.07 |
| CHEMBL4522174 | — | — | 2 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411879 | LATRUNCULIN B | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL4522174 | — | IC50 | = | 15210.0 | nM | 4.82 |
| CHEMBL4522174 | — | Inhibition | - | % | - | |
| CHEMBL411879 | LATRUNCULIN B | Inhibition | - | % | - |