Assay Detail
Binding
CHEMBL4336433
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Inhibition of Bcl6 (unknown origin) by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.32 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094351 | — | — | 1 | 8.54 |
| CHEMBL4448503 | — | — | 1 | 7.60 |
| CHEMBL4517433 | — | — | 1 | 6.72 |
| CHEMBL4077836 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094351 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4448503 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4517433 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4077836 | — | IC50 | = | 370.0 | nM | 6.43 |