Assay Detail
Binding
CHEMBL4336434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Mcl1 (unknown origin) by SPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.40 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448046 | — | — | 1 | 9.70 |
| CHEMBL4094351 | — | — | 1 | 8.19 |
| CHEMBL4473598 | — | — | 1 | 7.70 |
| CHEMBL4443085 | — | — | 1 | 7.03 |
| CHEMBL4460550 | — | — | 1 | 6.43 |
| CHEMBL4590345 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448046 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL4094351 | — | Kd | = | 6.5 | nM | 8.19 |
| CHEMBL4473598 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4443085 | — | Kd | = | 94.0 | nM | 7.03 |
| CHEMBL4460550 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4590345 | — | Kd | = | 4480.0 | nM | 5.35 |