Assay Detail
Binding
CHEMBL4336657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus CEN
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polymerase acidic protein (CHEMBL1169598) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.99 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3944613 | — | — | 1 | 8.30 |
| CHEMBL2443239 | — | — | 1 | 7.96 |
| CHEMBL4452342 | — | — | 1 | 7.85 |
| CHEMBL463590 | — | — | 1 | 6.37 |
| CHEMBL4457315 | — | — | 1 | 6.30 |
| CHEMBL2040602 | — | — | 1 | 6.10 |
| CHEMBL2070214 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3944613 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2443239 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4452342 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL463590 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4457315 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2040602 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2070214 | — | IC50 | = | 940.0 | nM | 6.03 |