Assay Detail
Binding
CHEMBL4337316
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Displacement of [3H]PK11195 from wild-type human TSPO expressed in HEK293 cells after 90 mins by scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.67 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459176 | — | — | 1 | 8.49 |
| CHEMBL416715 | (R)PK-11195 | — | 1 | 7.87 |
| CHEMBL4439049 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459176 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL416715 | (R)PK-11195 | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL4439049 | — | Ki | = | 217.3 | nM | 6.66 |