Assay Detail
Binding
CHEMBL4337404
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Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
[<sup>3</sup>H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H<sub>4</sub> Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.72 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454158 | — | — | 1 | 7.94 |
| CHEMBL4443126 | — | — | 1 | 7.59 |
| CHEMBL4439142 | — | — | 1 | 7.29 |
| CHEMBL4455324 | — | — | 1 | 6.87 |
| CHEMBL4445423 | — | — | 1 | 6.64 |
| CHEMBL4518374 | — | — | 1 | 6.45 |
| CHEMBL4543119 | — | — | 1 | 6.08 |
| CHEMBL4437371 | — | — | 1 | 5.97 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454158 | — | EC50 | = | 11.48 | nM | 7.94 |
| CHEMBL4443126 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4439142 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL4455324 | — | EC50 | = | 134.9 | nM | 6.87 |
| CHEMBL4445423 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL4518374 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL4543119 | — | EC50 | = | 831.76 | nM | 6.08 |
| CHEMBL4437371 | — | EC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL90 | HISTAMINE | EC50 | = | 2344.23 | nM | 5.63 |