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Assay Detail

CHEMBL4337639

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human DNA ligase 1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

DNA ligase 1 (CHEMBL5694)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.
Saquib M, Ansari MI, Johnson CR, Khatoon S, Kamil Hussain M, Coop A.
Eur J Med Chem (2019) 182 : 111657 -111657
PubMed 31499361 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2348305 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2348305 IC50 = 1000.0 nM 6.00