Assay Detail
Binding
CHEMBL4337640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 hrs by luciferase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Envelope glycoprotein gp160 (CHEMBL1293311) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Biological Evaluation of <i>m</i>-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.20 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474461 | — | — | 1 | 8.14 |
| CHEMBL4575700 | — | — | 1 | 7.97 |
| CHEMBL4579547 | — | — | 1 | 7.90 |
| CHEMBL4551966 | — | — | 1 | 7.65 |
| CHEMBL4476199 | — | — | 1 | 7.47 |
| CHEMBL4474236 | — | — | 1 | 7.02 |
| CHEMBL4552479 | — | — | 1 | 6.91 |
| CHEMBL4468452 | — | — | 1 | 6.89 |
| CHEMBL4588738 | — | — | 1 | 6.88 |
| CHEMBL4439355 | — | — | 1 | 6.87 |
| CHEMBL4578610 | — | — | 1 | 6.83 |
| CHEMBL4451659 | — | — | 1 | 6.78 |
| CHEMBL4545032 | — | — | 1 | 6.77 |
| CHEMBL4455835 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474461 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4575700 | — | EC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4579547 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL4551966 | — | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL4476199 | — | EC50 | = | 33.9 | nM | 7.47 |
| CHEMBL4474236 | — | EC50 | = | 95.7 | nM | 7.02 |
| CHEMBL4552479 | — | EC50 | = | 123.2 | nM | 6.91 |
| CHEMBL4468452 | — | EC50 | = | 127.3 | nM | 6.89 |
| CHEMBL4588738 | — | EC50 | = | 132.1 | nM | 6.88 |
| CHEMBL4439355 | — | EC50 | = | 136.4 | nM | 6.87 |
| CHEMBL4578610 | — | EC50 | = | 147.1 | nM | 6.83 |
| CHEMBL4451659 | — | EC50 | = | 166.2 | nM | 6.78 |
| CHEMBL4545032 | — | EC50 | = | 171.4 | nM | 6.77 |
| CHEMBL4455835 | — | EC50 | = | 213.6 | nM | 6.67 |