Assay Detail
Binding
CHEMBL4337765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FLT3 using EAIYAAPFAKKK substrate and [gamma-33P]-ATP by radiometric biochemical kinase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Unique Resorcylic Acid Lactone Derivative That Targets Both Lymphangiogenesis and Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.78 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012519 | — | — | 1 | 8.74 |
| CHEMBL4453304 | — | — | 1 | 8.36 |
| CHEMBL4515000 | — | — | 1 | 7.77 |
| CHEMBL4533447 | — | — | 1 | 7.39 |
| CHEMBL4452766 | — | — | 1 | 6.96 |
| CHEMBL4303275 | — | — | 1 | 6.54 |
| CHEMBL4515912 | — | — | 1 | 6.43 |
| CHEMBL4438318 | — | — | 1 | 5.34 |
| CHEMBL4517550 | — | — | 1 | 5.13 |
| CHEMBL4572320 | — | — | 1 | 5.11 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | - |
| CHEMBL4530473 | — | — | 1 | - |
| CHEMBL4520759 | — | — | 1 | - |
| CHEMBL4471009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012519 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4453304 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL4515000 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4533447 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4452766 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4303275 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4515912 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4438318 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL4517550 | — | IC50 | = | 7393.0 | nM | 5.13 |
| CHEMBL4572320 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL576982 | QUIZARTINIB | IC50 | < | 0.51 | nM | - |
| CHEMBL4530473 | — | IC50 | - | — | - | |
| CHEMBL4520759 | — | IC50 | - | — | - | |
| CHEMBL4471009 | — | IC50 | - | — | - |