Assay Detail
Functional
CHEMBL4337898
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Antiviral activity against Influenza A virus (A/California/04/2009(H1N1)) ATCC VR-1737 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by Cell-titer-Glo luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/California/04/2009(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.08 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | 2.0 | 1 | 5.66 |
| CHEMBL463590 | — | — | 1 | 5.13 |
| CHEMBL4440123 | — | — | 1 | 5.11 |
| CHEMBL4588964 | — | — | 1 | 4.98 |
| CHEMBL4551356 | — | — | 1 | 4.94 |
| CHEMBL4555466 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL463590 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4440123 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4588964 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4551356 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4555466 | — | EC50 | = | 21300.0 | nM | 4.67 |