Assay Detail
Binding
CHEMBL4337972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 peptide as substrate by FRET assay
122
Total Activities
122
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 122 | 5.08 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301728 | ACETYLPEPSTATIN | — | 1 | 6.62 |
| CHEMBL4456124 | — | — | 1 | 6.23 |
| CHEMBL4554132 | — | — | 1 | 6.10 |
| CHEMBL4437692 | — | — | 1 | 6.06 |
| CHEMBL4547137 | — | — | 1 | 6.00 |
| CHEMBL4442340 | — | — | 1 | 6.00 |
| CHEMBL4539603 | — | — | 1 | 5.92 |
| CHEMBL4436109 | — | — | 1 | 5.80 |
| CHEMBL4461755 | — | — | 1 | 5.66 |
| CHEMBL4589326 | — | — | 1 | 5.66 |
| CHEMBL4542116 | — | — | 1 | 5.64 |
| CHEMBL4530451 | — | — | 1 | 5.51 |
| CHEMBL4439699 | — | — | 1 | 5.50 |
| CHEMBL4576277 | — | — | 1 | 5.46 |
| CHEMBL4449440 | — | — | 1 | 5.34 |
| CHEMBL4445601 | — | — | 1 | 5.18 |
| CHEMBL4544704 | — | — | 1 | 5.02 |
| CHEMBL4521631 | — | — | 1 | 4.91 |
| CHEMBL4452290 | — | — | 1 | 4.75 |
| CHEMBL4455173 | — | — | 1 | 4.75 |
| CHEMBL4457431 | — | — | 1 | 4.70 |
| CHEMBL4467735 | — | — | 1 | 4.69 |
| CHEMBL4556934 | — | — | 1 | 4.63 |
| CHEMBL4434969 | — | — | 1 | 4.62 |
| CHEMBL4446985 | — | — | 1 | 4.52 |
| CHEMBL4457594 | — | — | 1 | 4.51 |
| CHEMBL4520771 | — | — | 1 | 4.49 |
| CHEMBL4516844 | — | — | 1 | 4.48 |
| CHEMBL4443019 | — | — | 1 | 4.41 |
| CHEMBL4469936 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301728 | ACETYLPEPSTATIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4456124 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4554132 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4437692 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4547137 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4442340 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4539603 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4436109 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4461755 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4589326 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4542116 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4530451 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4439699 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4576277 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4449440 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4445601 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4544704 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4521631 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4455173 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4452290 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4457431 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4467735 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4556934 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4434969 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4446985 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL4457594 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4520771 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL4516844 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4469936 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL4443019 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL4570395 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4468681 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL4445157 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL4465606 | — | IC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL4471963 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL4465430 | — | IC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 57700.0 | nM | 4.24 |
| CHEMBL4451914 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4541339 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4437082 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4570716 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4541946 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4578954 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4544245 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4567540 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4443113 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4471535 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4465146 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4546847 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4458924 | — | IC50 | > | 50000.0 | nM | - |