Assay Detail
Binding
CHEMBL4338312
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Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins followed by substrate addition and measured every 1 min
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.13 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180727 | — | — | 1 | 6.70 |
| CHEMBL4590233 | — | — | 1 | 4.93 |
| CHEMBL4562901 | — | — | 1 | 4.88 |
| CHEMBL4575450 | — | — | 1 | 4.76 |
| CHEMBL4580009 | — | — | 1 | 4.36 |
| CHEMBL4542803 | — | — | 1 | - |
| CHEMBL4439480 | — | — | 1 | - |
| CHEMBL4439930 | — | — | 1 | - |
| CHEMBL4442122 | — | — | 1 | - |
| CHEMBL4557972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180727 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4590233 | — | IC50 | = | 11660.0 | nM | 4.93 |
| CHEMBL4562901 | — | IC50 | = | 13310.0 | nM | 4.88 |
| CHEMBL4575450 | — | IC50 | = | 17310.0 | nM | 4.76 |
| CHEMBL4580009 | — | IC50 | = | 43580.0 | nM | 4.36 |
| CHEMBL4542803 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4439480 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4439930 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4442122 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4557972 | — | IC50 | > | 50000.0 | nM | - |