Assay Detail
Functional
CHEMBL4338328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against MIL resistant Leishmania infantum LEM 5159 isolate intracellular amastigotes infected in human THP1 cells after 96 hrs by prolong-gold antifade-reagent/DAPI staining based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.83 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455204 | — | — | 1 | 6.85 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455204 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 160.0 | nM | 6.80 |