Assay Detail
Functional
CHEMBL4338732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 6 | - | - |
| EC50 | 3 | 8.71 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564746 | — | — | 1 | 8.99 |
| CHEMBL415788 | — | — | 1 | 8.92 |
| CHEMBL4457798 | — | — | 1 | 8.23 |
| CHEMBL4534768 | — | — | 1 | - |
| CHEMBL4584647 | — | — | 1 | - |
| CHEMBL4537266 | — | — | 1 | - |
| CHEMBL4463399 | — | — | 1 | - |
| CHEMBL4592541 | — | — | 1 | - |
| CHEMBL4566971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564746 | — | EC50 | = | 1.023 | nM | 8.99 |
| CHEMBL415788 | — | EC50 | = | 1.202 | nM | 8.92 |
| CHEMBL4457798 | — | EC50 | = | 5.888 | nM | 8.23 |
| CHEMBL4534768 | — | pEC50 | - | — | - | |
| CHEMBL4584647 | — | pEC50 | - | — | - | |
| CHEMBL4537266 | — | pEC50 | - | — | - | |
| CHEMBL4463399 | — | pEC50 | - | — | - | |
| CHEMBL4592541 | — | pEC50 | - | — | - | |
| CHEMBL4566971 | — | pEC50 | - | — | - |