Assay Detail
Binding
CHEMBL4338736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.78 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415788 | — | — | 1 | 9.89 |
| CHEMBL4463399 | — | — | 1 | 9.12 |
| CHEMBL4457798 | — | — | 1 | 8.86 |
| CHEMBL4537266 | — | — | 1 | 8.70 |
| CHEMBL4534768 | — | — | 1 | 8.66 |
| CHEMBL4592541 | — | — | 1 | 8.57 |
| CHEMBL4566971 | — | — | 1 | 8.45 |
| CHEMBL4564746 | — | — | 1 | 8.38 |
| CHEMBL4584647 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415788 | — | Ki | = | 0.1288 | nM | 9.89 |
| CHEMBL4463399 | — | Ki | = | 0.7586 | nM | 9.12 |
| CHEMBL4457798 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL4537266 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL4534768 | — | Ki | = | 2.188 | nM | 8.66 |
| CHEMBL4592541 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL4566971 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL4564746 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL4584647 | — | Ki | = | 4.266 | nM | 8.37 |