Assay Detail
Binding
CHEMBL4338739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.90 | 8.20 |
| pKd | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457798 | — | — | 1 | 8.20 |
| CHEMBL4534768 | — | — | 1 | 7.99 |
| CHEMBL4564746 | — | — | 1 | 7.82 |
| CHEMBL4537266 | — | — | 1 | 7.59 |
| CHEMBL4584647 | — | — | 1 | - |
| CHEMBL4463399 | — | — | 1 | - |
| CHEMBL4592541 | — | — | 1 | - |
| CHEMBL4566971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457798 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL4534768 | — | Kd | = | 10.23 | nM | 7.99 |
| CHEMBL4564746 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL4537266 | — | Kd | = | 25.7 | nM | 7.59 |
| CHEMBL4584647 | — | pKd | - | — | - | |
| CHEMBL4463399 | — | pKd | - | — | - | |
| CHEMBL4592541 | — | pKd | - | — | - | |
| CHEMBL4566971 | — | pKd | - | — | - |