Assay Detail
Binding
CHEMBL4338810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus expression system using Ac-peptide as substrate incubated for 60 mins by fluorometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 6.96 |
| CHEMBL4444211 | — | — | 1 | 6.85 |
| CHEMBL4437428 | — | — | 1 | 6.82 |
| CHEMBL4519817 | — | — | 1 | - |
| CHEMBL4531117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4444211 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4437428 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4519817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4531117 | — | IC50 | > | 100000.0 | nM | - |