Assay Detail
Functional
CHEMBL4338833
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Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial <i>N</i> <sup>1</sup>,<i>N</i> <sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.78 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.55 |
| CHEMBL4442146 | — | — | 1 | 8.43 |
| CHEMBL4592955 | — | — | 1 | 8.40 |
| CHEMBL4439519 | — | — | 1 | 8.38 |
| CHEMBL4526792 | — | — | 1 | 8.37 |
| CHEMBL4573964 | — | — | 1 | 8.32 |
| CHEMBL4541717 | — | — | 1 | 8.32 |
| CHEMBL4562265 | — | — | 1 | 8.22 |
| CHEMBL4465998 | — | — | 1 | 8.19 |
| CHEMBL4580485 | — | — | 1 | 8.08 |
| CHEMBL4467123 | — | — | 1 | 7.94 |
| CHEMBL4528333 | — | — | 1 | 7.80 |
| CHEMBL4566141 | — | — | 1 | 7.73 |
| CHEMBL4552185 | — | — | 1 | 7.65 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.64 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.63 |
| CHEMBL4574158 | — | — | 1 | 7.59 |
| CHEMBL4473776 | — | — | 1 | 7.57 |
| CHEMBL2105734 | SEPANTRONIUM BROMIDE | 2.0 | 1 | 7.41 |
| CHEMBL4459470 | — | — | 1 | 7.38 |
| CHEMBL4530126 | — | — | 1 | 7.30 |
| CHEMBL4472124 | — | — | 1 | 7.21 |
| CHEMBL4524625 | — | — | 1 | 7.18 |
| CHEMBL4554378 | — | — | 1 | 6.74 |
| CHEMBL4567697 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4442146 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4592955 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4439519 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4526792 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4573964 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4541717 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4562265 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4465998 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4580485 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4467123 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL4528333 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL4566141 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL4552185 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL4574158 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4473776 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL2105734 | SEPANTRONIUM BROMIDE | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL4459470 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL4530126 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL4472124 | — | IC50 | = | 61.5 | nM | 7.21 |
| CHEMBL4524625 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL4554378 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4567697 | — | IC50 | = | 331.0 | nM | 6.48 |