Assay Detail
Functional
CHEMBL4338836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial <i>N</i> <sup>1</sup>,<i>N</i> <sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.18 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439519 | — | — | 1 | 8.62 |
| CHEMBL4465998 | — | — | 1 | 8.60 |
| CHEMBL4592955 | — | — | 1 | 8.51 |
| CHEMBL4559191 | — | — | 1 | 8.51 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.49 |
| CHEMBL4458088 | — | — | 1 | 8.47 |
| CHEMBL4458561 | — | — | 1 | 8.38 |
| CHEMBL4582800 | — | — | 1 | 8.36 |
| CHEMBL4543126 | — | — | 1 | 8.23 |
| CHEMBL4442146 | — | — | 1 | 8.19 |
| CHEMBL4559067 | — | — | 1 | 8.09 |
| CHEMBL4461205 | — | — | 1 | 8.01 |
| CHEMBL4438511 | — | — | 1 | 8.00 |
| CHEMBL4533385 | — | — | 1 | 7.95 |
| CHEMBL4556018 | — | — | 1 | 7.90 |
| CHEMBL4456232 | — | — | 1 | 7.88 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439519 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4465998 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4592955 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4559191 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.26 | nM | 8.49 |
| CHEMBL4458088 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4458561 | — | IC50 | = | 4.22 | nM | 8.38 |
| CHEMBL4582800 | — | IC50 | = | 4.42 | nM | 8.36 |
| CHEMBL4543126 | — | IC50 | = | 5.85 | nM | 8.23 |
| CHEMBL4442146 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4559067 | — | IC50 | = | 8.23 | nM | 8.09 |
| CHEMBL4461205 | — | IC50 | = | 9.85 | nM | 8.01 |
| CHEMBL4438511 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4533385 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4556018 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL4456232 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 154.0 | nM | 6.81 |