Assay Detail
Functional
CHEMBL4338838
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Antimalarial activity against Plasmodium falciparum NF54 early gametocytes transfected with luciferase gene incubated for 48 hrs by luciferase reporter gene assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial <i>N</i> <sup>1</sup>,<i>N</i> <sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.85 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559191 | — | — | 1 | 7.48 |
| CHEMBL4559067 | — | — | 1 | 7.41 |
| CHEMBL4458088 | — | — | 1 | 7.39 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.20 |
| CHEMBL4465998 | — | — | 1 | 7.14 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.02 |
| CHEMBL4543126 | — | — | 1 | 6.86 |
| CHEMBL4438511 | — | — | 1 | 6.84 |
| CHEMBL4592955 | — | — | 1 | 6.79 |
| CHEMBL4461205 | — | — | 1 | 6.74 |
| CHEMBL4458561 | — | — | 1 | 6.64 |
| CHEMBL4582800 | — | — | 1 | 6.57 |
| CHEMBL4439519 | — | — | 1 | 6.57 |
| CHEMBL4556018 | — | — | 1 | 6.47 |
| CHEMBL4533385 | — | — | 1 | 6.44 |
| CHEMBL4456232 | — | — | 1 | 6.43 |
| CHEMBL4442146 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559191 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4559067 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4458088 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4465998 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4543126 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4438511 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4592955 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4461205 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4458561 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4582800 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4439519 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4556018 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL4533385 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL4456232 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4442146 | — | IC50 | = | 390.0 | nM | 6.41 |