Assay Detail
Functional
CHEMBL4338855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum NF54 incubated for 48 hrs by [3H]-hypoxanthine incorporation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial <i>N</i> <sup>1</sup>,<i>N</i> <sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.84 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.40 |
| CHEMBL4439519 | — | — | 1 | 9.00 |
| CHEMBL4592955 | — | — | 1 | 9.00 |
| CHEMBL4465998 | — | — | 1 | 9.00 |
| CHEMBL4442146 | — | — | 1 | 8.92 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.49 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4439519 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4592955 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4465998 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4442146 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 8.6 | nM | 8.07 |