Assay Detail
Binding
CHEMBL4339112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal GST-tagged IDO1 expressed in Escherichia coli Rosetta(DE3) pLysS using L-tryptophan as substrate measured after 1 hr by fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.92 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585089 | — | — | 1 | 7.68 |
| CHEMBL4441030 | — | — | 1 | 7.52 |
| CHEMBL4578545 | — | — | 1 | 7.21 |
| CHEMBL4437616 | — | — | 1 | 7.16 |
| CHEMBL4448442 | — | — | 1 | 7.15 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL4455438 | — | — | 1 | 7.14 |
| CHEMBL4439896 | — | — | 1 | 7.08 |
| CHEMBL4451194 | — | — | 1 | 7.03 |
| CHEMBL4549976 | — | — | 1 | 7.03 |
| CHEMBL4441246 | — | — | 1 | 7.00 |
| CHEMBL4434929 | — | — | 1 | 6.96 |
| CHEMBL4475499 | — | — | 1 | 6.89 |
| CHEMBL4452336 | — | — | 1 | 6.89 |
| CHEMBL4521926 | — | — | 1 | 6.85 |
| CHEMBL4449948 | — | — | 1 | 6.85 |
| CHEMBL4436560 | — | — | 1 | 6.85 |
| CHEMBL4465837 | — | — | 1 | 6.82 |
| CHEMBL4483087 | — | — | 1 | 6.82 |
| CHEMBL4538516 | — | — | 1 | 6.75 |
| CHEMBL584991 | — | — | 1 | 6.68 |
| CHEMBL4545974 | — | — | 1 | 6.64 |
| CHEMBL4461796 | — | — | 1 | 6.62 |
| CHEMBL4533342 | — | — | 1 | 6.57 |
| CHEMBL4533432 | — | — | 1 | 6.44 |
| CHEMBL4573030 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585089 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4441030 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4578545 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4437616 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4448442 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4455438 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4439896 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4451194 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4549976 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4441246 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4434929 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4475499 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4452336 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4521926 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4449948 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4436560 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4465837 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4483087 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4538516 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL584991 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4545974 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4461796 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4533342 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4533432 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4573030 | — | IC50 | = | 560.0 | nM | 6.25 |