Assay Detail
Binding
CHEMBL4339113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in interferon-gamma-induced human SKOV3 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 24 hrs by fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.89 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452336 | — | — | 1 | 8.55 |
| CHEMBL4538516 | — | — | 1 | 8.19 |
| CHEMBL4436560 | — | — | 1 | 8.12 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.10 |
| CHEMBL4441030 | — | — | 1 | 8.09 |
| CHEMBL4521926 | — | — | 1 | 8.08 |
| CHEMBL4533342 | — | — | 1 | 8.03 |
| CHEMBL4585089 | — | — | 1 | 8.00 |
| CHEMBL4434929 | — | — | 1 | 7.92 |
| CHEMBL4448442 | — | — | 1 | 7.92 |
| CHEMBL4483087 | — | — | 1 | 7.92 |
| CHEMBL4449948 | — | — | 1 | 7.92 |
| CHEMBL4437616 | — | — | 1 | 7.89 |
| CHEMBL4439896 | — | — | 1 | 7.89 |
| CHEMBL4455438 | — | — | 1 | 7.89 |
| CHEMBL4578545 | — | — | 1 | 7.85 |
| CHEMBL4441246 | — | — | 1 | 7.85 |
| CHEMBL584991 | — | — | 1 | 7.85 |
| CHEMBL4573030 | — | — | 1 | 7.82 |
| CHEMBL4533432 | — | — | 1 | 7.80 |
| CHEMBL4475499 | — | — | 1 | 7.77 |
| CHEMBL4451194 | — | — | 1 | 7.72 |
| CHEMBL4549976 | — | — | 1 | 7.68 |
| CHEMBL4545974 | — | — | 1 | 7.41 |
| CHEMBL4465837 | — | — | 1 | 7.41 |
| CHEMBL4461796 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452336 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4538516 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4436560 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4441030 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4521926 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4533342 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4585089 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4434929 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4448442 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4483087 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4449948 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4437616 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4439896 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4455438 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4578545 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4441246 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL584991 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4573030 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4533432 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4475499 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4451194 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4549976 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4545974 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4465837 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4461796 | — | IC50 | = | 44.0 | nM | 7.36 |