Assay Detail
Binding
CHEMBL4339267
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Inhibition of HDAC1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.33 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.85 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 8.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 42.5 | nM | 7.37 |