Assay Detail
Binding
CHEMBL4339338
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Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 10 mins by spectrophotometry based Ellman's method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.93 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447258 | — | — | 1 | 7.18 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.65 |
| CHEMBL4542112 | — | — | 1 | 6.36 |
| CHEMBL4441059 | — | — | 1 | 6.27 |
| CHEMBL4466829 | — | — | 1 | 6.26 |
| CHEMBL4458648 | — | — | 1 | 6.21 |
| CHEMBL4459154 | — | — | 1 | 6.10 |
| CHEMBL4444030 | — | — | 1 | 6.09 |
| CHEMBL4435178 | — | — | 1 | 6.07 |
| CHEMBL4525409 | — | — | 1 | 6.04 |
| CHEMBL4445026 | — | — | 1 | 6.04 |
| CHEMBL4557164 | — | — | 1 | 5.88 |
| CHEMBL4556651 | — | — | 1 | 5.87 |
| CHEMBL4580216 | — | — | 1 | 5.73 |
| CHEMBL4553902 | — | — | 1 | 5.68 |
| CHEMBL4435058 | — | — | 1 | 5.42 |
| CHEMBL4443988 | — | — | 1 | 5.36 |
| CHEMBL4526428 | — | — | 1 | 4.74 |
| CHEMBL4592037 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447258 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL95 | TACRINE | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4542112 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL4441059 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL4466829 | — | IC50 | = | 546.7 | nM | 6.26 |
| CHEMBL4458648 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL4459154 | — | IC50 | = | 792.0 | nM | 6.10 |
| CHEMBL4444030 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL4435178 | — | IC50 | = | 861.0 | nM | 6.07 |
| CHEMBL4525409 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4445026 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL4557164 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4556651 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4580216 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4553902 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL4435058 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4443988 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL4526428 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4592037 | — | IC50 | = | 20200.0 | nM | 4.70 |