Assay Detail
Binding
CHEMBL4339345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 10 mins by Ellman's method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.08 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 8.07 |
| CHEMBL4466829 | — | — | 1 | 7.87 |
| CHEMBL4458648 | — | — | 1 | 7.59 |
| CHEMBL4445026 | — | — | 1 | 7.58 |
| CHEMBL4447258 | — | — | 1 | 7.13 |
| CHEMBL4441059 | — | — | 1 | 7.12 |
| CHEMBL4542112 | — | — | 1 | 7.11 |
| CHEMBL4580216 | — | — | 1 | 6.74 |
| CHEMBL4435058 | — | — | 1 | 6.73 |
| CHEMBL4435178 | — | — | 1 | 6.59 |
| CHEMBL4459154 | — | — | 1 | 6.44 |
| CHEMBL4525409 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 8.45 | nM | 8.07 |
| CHEMBL4466829 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4458648 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL4445026 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL4447258 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL4441059 | — | IC50 | = | 75.3 | nM | 7.12 |
| CHEMBL4542112 | — | IC50 | = | 77.9 | nM | 7.11 |
| CHEMBL4580216 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4435058 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4435178 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL4459154 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL4525409 | — | IC50 | = | 942.2 | nM | 6.03 |