Assay Detail
Functional
CHEMBL4339347
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
63
Total Activities
61
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.20 | 5.92 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 2 | 5.92 |
| CHEMBL4555038 | — | — | 2 | 5.77 |
| CHEMBL4567570 | — | — | 1 | 5.63 |
| CHEMBL4581472 | — | — | 1 | 5.62 |
| CHEMBL4515889 | — | — | 1 | 5.59 |
| CHEMBL4483682 | — | — | 1 | 5.56 |
| CHEMBL4552732 | — | — | 1 | 5.53 |
| CHEMBL4459545 | — | — | 1 | 5.49 |
| CHEMBL4567288 | — | — | 1 | 5.48 |
| CHEMBL379849 | — | — | 1 | 5.48 |
| CHEMBL4441873 | — | — | 1 | 5.45 |
| CHEMBL4444166 | — | — | 1 | 5.44 |
| CHEMBL4443170 | — | — | 1 | 5.40 |
| CHEMBL4438372 | — | — | 1 | 5.39 |
| CHEMBL4542771 | — | — | 1 | 5.38 |
| CHEMBL4533824 | — | — | 1 | 5.36 |
| CHEMBL4458569 | — | — | 1 | 5.35 |
| CHEMBL4444193 | — | — | 1 | 5.34 |
| CHEMBL4561140 | — | — | 1 | 5.34 |
| CHEMBL4519583 | — | — | 1 | 5.33 |
| CHEMBL4539465 | — | — | 1 | 5.32 |
| CHEMBL4591042 | — | — | 1 | 5.32 |
| CHEMBL4576186 | — | — | 1 | 5.32 |
| CHEMBL4587685 | — | — | 1 | 5.30 |
| CHEMBL4451513 | — | — | 1 | 5.30 |
| CHEMBL4471501 | — | — | 1 | 5.29 |
| CHEMBL4546168 | — | — | 1 | 5.28 |
| CHEMBL4520076 | — | — | 1 | 5.28 |
| CHEMBL4533881 | — | — | 1 | 5.27 |
| CHEMBL4449451 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4555038 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4567570 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4581472 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4515889 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4483682 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL4552732 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL4459545 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL379849 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL4567288 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4441873 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4444166 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL4443170 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL4438372 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4542771 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4533824 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL4458569 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4444193 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4561140 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL4519583 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL4539465 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4576186 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL4591042 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4587685 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL4451513 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4471501 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL4546168 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4520076 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4533881 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL4449451 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4455252 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL4450178 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4455021 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4463834 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL4588028 | — | IC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL4458916 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL4574874 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL4461518 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4472393 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL4473881 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4515253 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4554605 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4537334 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4555429 | — | IC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL4472312 | — | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL4533676 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4539859 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4475718 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4465295 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4466963 | — | IC50 | = | 11700.0 | nM | 4.93 |