Assay Detail
Functional
CHEMBL4339349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
63
Total Activities
61
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.03 | 5.76 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4555038 | — | — | 2 | 5.76 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 2 | 5.56 |
| CHEMBL4459545 | — | — | 1 | 5.42 |
| CHEMBL4515889 | — | — | 1 | 5.41 |
| CHEMBL4567288 | — | — | 1 | 5.39 |
| CHEMBL4450178 | — | — | 1 | 5.35 |
| CHEMBL4576186 | — | — | 1 | 5.32 |
| CHEMBL4444166 | — | — | 1 | 5.31 |
| CHEMBL4451513 | — | — | 1 | 5.29 |
| CHEMBL4539465 | — | — | 1 | 5.27 |
| CHEMBL4574874 | — | — | 1 | 5.26 |
| CHEMBL4519583 | — | — | 1 | 5.25 |
| CHEMBL4591042 | — | — | 1 | 5.24 |
| CHEMBL4483682 | — | — | 1 | 5.24 |
| CHEMBL4533676 | — | — | 1 | 5.24 |
| CHEMBL4463834 | — | — | 1 | 5.21 |
| CHEMBL4567570 | — | — | 1 | 5.19 |
| CHEMBL4458916 | — | — | 1 | 5.18 |
| CHEMBL4552732 | — | — | 1 | 5.17 |
| CHEMBL4444193 | — | — | 1 | 5.16 |
| CHEMBL4581472 | — | — | 1 | 5.10 |
| CHEMBL379849 | — | — | 1 | 5.06 |
| CHEMBL4475718 | — | — | 1 | 5.04 |
| CHEMBL4441873 | — | — | 1 | 5.04 |
| CHEMBL4515253 | — | — | 1 | 5.04 |
| CHEMBL4443170 | — | — | 1 | 5.03 |
| CHEMBL4520076 | — | — | 1 | 5.02 |
| CHEMBL4455252 | — | — | 1 | 5.02 |
| CHEMBL4587685 | — | — | 1 | 5.01 |
| CHEMBL4533824 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4555038 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4459545 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4515889 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4567288 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4450178 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4576186 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL4444166 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4451513 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4539465 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4574874 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4519583 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL4533676 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4483682 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL4591042 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL4463834 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL4567570 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL4458916 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL4552732 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4444193 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4581472 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL379849 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4441873 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4475718 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL4515253 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4443170 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL4520076 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4455252 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4587685 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL4533824 | — | IC50 | = | 9830.0 | nM | 5.01 |
| CHEMBL4570251 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4542771 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4518441 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4561140 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4438372 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4533881 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4537334 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4539859 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4466963 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4460910 | — | IC50 | = | 13620.0 | nM | 4.87 |
| CHEMBL4471501 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4546168 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4455021 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4465295 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4555429 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4542761 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4458569 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL140 | CURCUMIN | IC50 | = | 16680.0 | nM | 4.78 |
| CHEMBL4449451 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4461518 | — | IC50 | = | 17700.0 | nM | 4.75 |