Assay Detail
Functional
CHEMBL4339416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of daunorubicin-induced cytotoxicity against patient-derived T-ALL (COG-329h) cells assessed as daunorubicin IC50 measured after 72 hrs by cellTiter 96 aqueous one solution reagent based assay (Rvb = 0.07 uM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-ALL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473138 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473138 | — | IC50 | = | 6.0 | nM | 8.22 |