Assay Detail
Binding
CHEMBL4339840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of rat LXRbeta expressed in HEK293FT cells measured after 14 to 18 hrs by dual-luciferase reporter gene assay
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxysterols receptor LXR-beta (CHEMBL4105785) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structural requirements of cholenamide derivatives as the LXR ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.32 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.52 |
| CHEMBL352837 | — | — | 1 | 6.91 |
| CHEMBL4517743 | — | — | 1 | 6.90 |
| CHEMBL4443761 | — | — | 1 | 6.78 |
| CHEMBL4454474 | — | — | 1 | 6.62 |
| CHEMBL2418972 | — | — | 1 | 6.46 |
| CHEMBL4451363 | — | — | 1 | 6.33 |
| CHEMBL4449081 | — | — | 1 | 6.21 |
| CHEMBL4579836 | — | — | 1 | 6.19 |
| CHEMBL4538857 | — | — | 1 | 6.11 |
| CHEMBL4531360 | — | — | 1 | 6.06 |
| CHEMBL4456655 | — | — | 1 | 5.99 |
| CHEMBL4462094 | — | — | 1 | 5.96 |
| CHEMBL4537679 | — | — | 1 | 5.89 |
| CHEMBL4435008 | — | — | 2 | 5.70 |
| CHEMBL4442540 | — | — | 1 | - |
| CHEMBL4452935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL352837 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4517743 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4443761 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL4454474 | — | EC50 | = | 239.0 | nM | 6.62 |
| CHEMBL2418972 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL4451363 | — | EC50 | = | 462.0 | nM | 6.33 |
| CHEMBL4449081 | — | EC50 | = | 623.0 | nM | 6.21 |
| CHEMBL4579836 | — | EC50 | = | 643.0 | nM | 6.19 |
| CHEMBL4538857 | — | EC50 | = | 786.0 | nM | 6.11 |
| CHEMBL4531360 | — | EC50 | = | 862.0 | nM | 6.06 |
| CHEMBL4456655 | — | EC50 | = | 1024.0 | nM | 5.99 |
| CHEMBL4462094 | — | EC50 | = | 1107.0 | nM | 5.96 |
| CHEMBL4537679 | — | EC50 | = | 1291.0 | nM | 5.89 |
| CHEMBL4435008 | — | EC50 | = | 1992.0 | nM | 5.70 |
| CHEMBL4435008 | — | EC50 | = | 3896.0 | nM | 5.41 |
| CHEMBL4442540 | — | EC50 | - | — | - | |
| CHEMBL4452935 | — | EC50 | - | — | - |