Assay Detail
Functional
CHEMBL4339844
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Cytotoxicity against human U937 cells assessed as reduction in cell viability measured after 3 days by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.66 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 8.70 |
| CHEMBL4446237 | — | — | 1 | 6.75 |
| CHEMBL4554661 | — | — | 1 | 6.20 |
| CHEMBL4573488 | — | — | 1 | 6.16 |
| CHEMBL4463927 | — | — | 1 | 6.11 |
| CHEMBL4566643 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4446237 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4554661 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4573488 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4463927 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4566643 | — | IC50 | = | 880.0 | nM | 6.06 |