Assay Detail
Functional
CHEMBL4340095
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.93 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4539177 | — | — | 1 | 5.10 |
| CHEMBL4456805 | — | — | 1 | 5.10 |
| CHEMBL2363137 | — | — | 1 | 5.00 |
| CHEMBL4584542 | — | — | 1 | 4.89 |
| CHEMBL4449346 | — | — | 1 | 4.82 |
| CHEMBL4527356 | — | — | 1 | 4.80 |
| CHEMBL4536754 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4539177 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4456805 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2363137 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4584542 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4449346 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4527356 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4536754 | — | IC50 | = | 17000.0 | nM | 4.77 |