Assay Detail
Binding
CHEMBL4340096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NHERF1 in human SW620 cells expressing NHERF1 assessed as inhibition cell growth incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (CHEMBL4523125) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.66 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4539177 | — | — | 1 | 4.89 |
| CHEMBL4456805 | — | — | 1 | 4.77 |
| CHEMBL2363137 | — | — | 1 | 4.72 |
| CHEMBL4536754 | — | — | 1 | 4.66 |
| CHEMBL4584542 | — | — | 1 | 4.57 |
| CHEMBL4449346 | — | — | 1 | 4.52 |
| CHEMBL4527356 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4539177 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4456805 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2363137 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4536754 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4584542 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4449346 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4527356 | — | IC50 | = | 31000.0 | nM | 4.51 |