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Assay Detail

CHEMBL4340103

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Wnt signaling pathway in LiCl-induced HEK293T cells incubated for 24 hrs by TOPFlash reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents.
Coluccia A, La Regina G, Naccarato V, Nalli M, Orlando V, Biagioni S, De Angelis ML, Baiocchi M, Gautier C, Gianni S, Di Pastena F, Di Magno L, Canettieri G, Coluccia AML, Silvestri R.
ACS Med Chem Lett (2019) 10 : 499 -503
PubMed 30996786 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.85 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4456805 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4456805 IC50 = 14100.0 nM 4.85